{"slug":"tb-500","seoKey":"tb500","displayName":"TB-500","codes":["TB500","TB 500","Ac-LKKTETQ"],"synonyms":["thymosin beta-4 fragment (LKKTETQ)","thymosin beta 4 (17-23)","Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln-OH","TB-500 acetate","TB1000 (trade designation of a supposedly stronger variant)"],"legalClass":"research_chemical","identifiers":{"cas":"885340-08-9","pubchemCid":62707662,"unii":"QHK6Z47GTG","inchikey":"ADKDNDYYIZUVCZ-ZQNQAVPYSA-N","wikidataQid":"Q137400007","formula":"C38H68N10O14","molecularWeight":889,"sequence":"Ac-LKKTETQ"},"approvals":[{"market":"US","status":"not_approved","note":"Not approved in any indication or dosage form, for humans or animals. Listed among the bulk drug substances previously in category 2 of the interim compounding policies whose nomination was withdrawn; the agency states it identified no human exposure data at all.","source":"https://www.fda.gov/drugs/human-drug-compounding/certain-bulk-drug-substances-use-compounding-may-present-significant-safety-risks"},{"market":"EU","status":"not_approved","note":"No centralised marketing authorisation and no assessment report. No entry found on 2026-09-06.","source":"https://www.ema.europa.eu/en/medicines?search_api_fulltext=TB-500"},{"market":"DE","status":"not_approved","note":"No national or EU marketing authorisation and no food supplement status. The trade designation as a research chemical is not a legal category. No entry found on 2026-09-06.","source":"https://www.ema.europa.eu/en/medicines?search_api_fulltext=TB-500"},{"market":"UK","status":"not_approved","note":"No marketing authorisation; treated as an unlicensed medicine and not a controlled drug. No entry found on 2026-09-06.","source":"https://products.mhra.gov.uk/search/?search=TB-500"},{"market":"AU","status":"scheduled","date":"2024-06-01","note":"Listed by name in the Poisons Standard as Schedule 4 (prescription only) and in Appendix D, clause 5, which makes possession without authority unlawful. The full-length parent protein carries a separate entry of its own.","source":"https://www.legislation.gov.au/F2024L00589/asmade/text"},{"market":"CA","status":"not_approved","note":"No marketing authorisation, no drug identification number and not a permitted natural health product ingredient. No entry found on 2026-09-06.","source":"https://health-products.canada.ca/api/drug/activeingredient/?ingredientname=TB-500"},{"market":"CH","status":"not_approved","note":"No marketing authorisation. No entry found in the Swiss medicinal product information on 2026-09-06.","source":"https://www.swissmedicinfo.ch/"}],"devStage":"preclinical","strongestEvidence":"animal","wada":{"status":"prohibited","section":"S2","listYear":2026,"source":"https://www.wada-ama.org/en/prohibited-list"},"trials":[],"sameAs":["https://www.wikidata.org/wiki/Q137400007","https://pubchem.ncbi.nlm.nih.gov/compound/62707662"],"lastVerified":"2026-09-06","version":"1.0","published":true,"locale":"en","title":"TB-500: what the studies show, status and safety","summary":"TB-500 is a lab-made piece of seven building blocks taken from the human protein thymosin β4. No authority has approved it, and the FDA states that it found no data whatsoever on people taking it. Every published effect comes from animals or from cells in a dish. Almost every clinical trial in this field tested the complete protein of 43 building blocks instead, and the two largest of those trials failed on the questions they set out to answer.","updated":"2026-09-06","url":"https://mypep.app/peptides/tb-500"}