{"slug":"pe-22-28","seoKey":"pe2228","displayName":"PE-22-28","codes":["PE 22-28","PE(22-28)"],"synonyms":["mini-spadin","spadin analogue","TREK-1 blocker peptide","GVSWGLR","Gly-Val-Ser-Trp-Gly-Leu-Arg","sortilin propeptide (22-28)","spadin (the longer parent molecule is a DIFFERENT substance)"],"legalClass":"research_chemical","identifiers":{"cas":"1801959-12-5","pubchemCid":165437303,"inchikey":"CMNBQRXBBJQIOA-YIHYGEMESA-N","formula":"C35H55N11O9","molecularWeight":773.9,"sequence":"GVSWGLR"},"approvals":[{"market":"US","status":"not_approved","note":"Not approved, not part of any approved medicinal product and no pharmacopoeial monograph. Not on any compounding list and never nominated for one; a full-text search of both list pages on 2026-09-07 returned no entry, verified by a working control query. Not a recognised food supplement ingredient either.","source":"https://www.fda.gov/drugs/human-drug-compounding/bulk-drug-substances-used-compounding-under-section-503a-fdc-act"},{"market":"EU","status":"not_approved","note":"No marketing authorisation and no monograph in the European Pharmacopoeia. There is no international nonproprietary name, no anatomical therapeutic chemical code and no substance identifier through which an authorisation could exist.","source":"https://www.ema.europa.eu/en/medicines?search_api_fulltext=spadin"},{"market":"DE","status":"not_approved","note":"No marketing authorisation; a substance with a medicinal purpose may not be placed on the market without one. Named neither in narcotics legislation nor in the annex to the anti-doping act.","source":"https://www.gesetze-im-internet.de/amg_1976/__21.html"},{"market":"UK","status":"not_approved","note":"No marketing authorisation found on 2026-09-07.","source":"https://products.mhra.gov.uk/search/?search=spadin"},{"market":"AU","status":"not_approved","note":"No marketing authorisation and not named in the Poisons Standard. Unlike some other grey-market peptides, the regulator has not captured this substance by name; as an unapproved therapeutic good it nevertheless remains regulated. The absence was not confirmed by a full-text search of the current instrument.","source":"https://www.legislation.gov.au/F2026L00633/asmade"},{"market":"CA","status":"not_approved","note":"No marketing authorisation and no entry found in the drug product database on 2026-09-07.","source":"https://health-products.canada.ca/api/drug/activeingredient/?ingredientname=spadin"},{"market":"CH","status":"not_approved","note":"No marketing authorisation found on 2026-09-07.","source":"https://www.swissmedicinfo.ch/"}],"devStage":"preclinical","strongestEvidence":"animal","wada":{"status":"prohibited","section":"S0","listYear":2026,"source":"https://www.wada-ama.org/en/prohibited-list"},"trials":[],"sameAs":["https://pubchem.ncbi.nlm.nih.gov/compound/165437303","https://www.uniprot.org/uniprotkb/Q99523/entry"],"lastVerified":"2026-09-07","version":"1.0","published":true,"locale":"en","title":"PE-22-28: what the studies show, status and safety","summary":"PE-22-28 is a lab-made peptide of seven building blocks, sold online as a research chemical. Almost everything known comes from one paper published in 2017 by one French research group, which reported that mice floated less in a swim test. Nobody has taken it in a study, no toxicity data exist, and the one independent check came out largely negative.","updated":"2026-09-07","url":"https://mypep.app/peptides/pe-22-28"}