{"slug":"ovagen","seoKey":"ovagen","displayName":"Ovagen","codes":["T-35","AC-3"],"synonyms":["Glu-Asp-Leu","EDL","EDL peptide","H-Glu-Asp-Leu-OH","L-glutamyl-L-aspartyl-L-leucine","glutamyl-aspartyl-leucine (the NLM MeSH supplementary concept heading)","T-35 peptide","Ovagen / Оваген (Russian spelling)"],"legalClass":"research_chemical","identifiers":{"pubchemCid":444128,"inchikey":"JVSBYEDSSRZQGV-GUBZILKMSA-N","formula":"C15H25N3O8","molecularWeight":375.37,"sequence":"EDL"},"approvals":[{"market":"US","status":"not_approved","date":"2026-09-16","note":"Not approved and not registered as a substance. Federal queries returned nothing for the peptide on 16 September 2026: no record in the substance registration system, which is why there is no substance code, no label under the chemical name and no adverse event report. The control query for an approved medicine returned five substance records, so the interface was working. The substance was also never put forward for the compounding bulks list, whose full text was read; two short peptides do stand in that list, so this is an absence and not an oversight. Care is needed with the one label record that the query for the trade name does return: it is a homeopathic drop product of the same name with an entirely different composition, not this peptide. No warning letter naming this substance was found, although sellers of other peptides received a series of them during 2026.","source":"https://gsrs.ncats.nih.gov"},{"market":"EU","status":"not_approved","date":"2026-09-16","note":"No centralised marketing authorisation, no assessment report and no withdrawal document. The register itself could not be queried on 16 September 2026 because the agency site answered an automated request with HTTP 403, so this is a negative finding drawn from the absence of any entry in every other authority database checked and from the absence of any registered trial. Recorded as an unverified gap rather than a nil result.","source":"https://www.ema.europa.eu/en/medicines"},{"market":"DE","status":"not_approved","date":"2026-09-16","note":"Neither a national nor an EU marketing authorisation exists, so an injectable preparation is not a marketable medicinal product and may not be imported or dispensed. The Russian capsule form does not become marketable by being imported either: a synthetic tripeptide without a meaningful history of consumption in Europe before 15 May 1997 counts as a novel food and would need its own authorisation, and none was found. The substance is also not named in the schedule to the Anti-Doping Act, whose full text was checked on 16 September 2026: section II lists peptide hormones, releasing factors and growth factors one by one, the closing sentence extends only to salts, esters and derivatives of those named substances, and no catch-all position covers a tripeptide without hormone activity. Possession is therefore not an offence under that provision, which changes nothing about the sporting ban.","source":"https://www.gesetze-im-internet.de/antidopg/anlage.html"},{"market":"UK","status":"not_approved","date":"2026-09-16","note":"No marketing authorisation known. The product register returned only the JavaScript shell of its search page on 16 September 2026, and the query and a control query produced byte-identical answers of 122,696 characters each, so the negative finding could not be verified positively. It rests on the absence of any entry elsewhere and on the absence of any clinical development.","source":"https://products.mhra.gov.uk/"},{"market":"AU","status":"not_approved","date":"2026-09-16","note":"Not named in the Poisons Standard; the full text of the June 2026 instrument was searched on 16 September 2026 for the trade name, the sequence and the amino acid names without a hit, while two short peptides were found by name, so the search worked and short peptides are covered individually when they are covered at all. There is no generic peptide position in that instrument. Absence of a listing is not a clearance: unapproved research peptides remain subject to the rules for therapeutic goods, and the registry itself was not programmatically queryable on the day of checking.","source":"https://www.legislation.gov.au/F2026L00633/asmade"},{"market":"CA","status":"not_approved","date":"2026-09-16","note":"The peptide holds no marketing authorisation. The drug product database does return exactly one record for the brand name on 16 September 2026, and it is the one most often misread: a veterinary product, drug code 82325, identification number 02337673, company ICPbio Reproduction, approved since 18 November 2009 and last updated 26 June 2026, whose active ingredient is follicle stimulating hormone from sheep at 17.6 mg per vial. That is a hormone preparation for farm animals and has nothing in common with a chain of three amino acids. The registry number printed by sellers of the peptide belongs to that sheep hormone.","source":"https://health-products.canada.ca/api/drug/drugproduct/?lang=en&type=json&brandname=ovagen"},{"market":"CH","status":"not_approved","date":"2026-09-16","note":"No marketing authorisation known. The register was unreachable on 16 September 2026, so no direct query was possible; this is a negative finding drawn from the absence of an authorisation in every market that could be checked and from the absence of any clinical development programme. Recorded as an unverified gap rather than a nil result.","source":"https://www.swissmedic.ch/"}],"devStage":"preclinical","strongestEvidence":"animal","wada":{"status":"prohibited","section":"S0","listYear":2026,"source":"https://www.wada-ama.org/en/prohibited-list"},"trials":[],"sameAs":["https://pubchem.ncbi.nlm.nih.gov/compound/444128"],"lastVerified":"2026-09-16","version":"1.0","published":true,"locale":"en","title":"Ovagen: what the studies show, status and safety","summary":"Ovagen is a synthetic chain of three amino acids, Glu-Asp-Leu, made at a St Petersburg institute. It is sold as a liver and digestive peptide, but every reviewed experiment published on it was done on kidneys. Not one reviewed study has tested it on liver or gut tissue, and not one study in people has ever been registered. It is approved as a medicine nowhere, including Russia, where it is sold only as a capsule food supplement. The same trade name belongs to an approved veterinary hormone and to a homeopathic product.","updated":"2026-09-16","url":"https://mypep.app/peptides/ovagen"}