{"slug":"cjc-1295-dac","seoKey":"cjc1295dac","displayName":"CJC-1295 DAC","codes":["CJC-1295 DAC","DAC:GRF"],"synonyms":["CJC-1295 with DAC","drug affinity complex GRF","DAC-GRF","GRF 1-29 (CJC1295)","Drug Affinity Complex:Growth Hormone-Releasing Factor","N-epsilon30-maleimidopropionyl-[D-Ala2, Gln8, Ala15, Leu27]-hGRF(1-29)-Lys30-NH2"],"legalClass":"research_chemical","identifiers":{"cas":"446262-90-4","pubchemCid":91971820,"unii":"62RC32V9N7","inchikey":"ZUQGTWKGESAQCD-ZGFIGYLBSA-N","formula":"C165H269N47O46","molecularWeight":3647.2,"sequence":"Y-(D-A)-DAIFTQSYRKVLAQLSARKLLQDILSR-K30-NH2"},"approvals":[{"market":"US","status":"not_approved","note":"Not approved in any indication and on neither compounding list. Named on the regulator's list of bulk drug substances that may present significant safety risks, in the section for nominations withdrawn by the nominators.","source":"https://www.fda.gov/drugs/human-drug-compounding/certain-bulk-drug-substances-use-compounding-may-present-significant-safety-risks"},{"market":"EU","status":"not_approved","note":"No centralised marketing authorisation; a marketing application was never filed, because development ended in phase 2 in 2006. The regulator's search refused automated queries on 2026-09-07, so the finding rests on the development history and on the reviewed literature.","source":"https://www.ema.europa.eu/en/medicines?search_api_fulltext=CJC-1295"},{"market":"DE","status":"not_approved","note":"No national or EU marketing authorisation, so no finished medicinal product may be placed on the market. Growth hormone releasing factors are covered by the annex to the German anti-doping act; labelling a product as a research chemical does not change that.","source":"https://www.gesetze-im-internet.de/antidopg/anlage.html"},{"market":"UK","status":"not_approved","note":"No marketing authorisation and no safety notice; a full-text search of the government portal on 2026-09-07 returned no relevant entry.","source":"https://products.mhra.gov.uk/search/?search=CJC-1295"},{"market":"AU","status":"scheduled","date":"2026-05-28","note":"Named in the Poisons Standard in Schedule 4 (prescription only) and in Appendix D, clause 5, headed 'Poisons for which possession without authority is illegal'. No registered finished medicine exists, so no lawful supply route accompanies the prescription requirement.","source":"https://www.legislation.gov.au/F2026L00633/asmade"},{"market":"CA","status":"not_approved","note":"No marketing authorisation and no drug identification number; the active ingredient query returned no result on 2026-09-07. The developer was a Canadian company, so the substance was never authorised in its country of origin.","source":"https://health-products.canada.ca/api/drug/activeingredient/?ingredientname=CJC-1295"},{"market":"CH","status":"not_approved","note":"No marketing authorisation. A joint customs, medicines agency and sport integrity operation on peptides on 2026-06-22 states that distributing or drop-shipping unauthorised medicines within the country is unlawful.","source":"https://www.swissmedicinfo.ch/"}],"devStage":"discontinued","strongestEvidence":"rct_phase1","wada":{"status":"prohibited","section":"S2.2.4","listYear":2026,"source":"https://www.wada-ama.org/en/prohibited-list"},"trials":[{"nct":"NCT00267527","name":"HIV-associated visceral obesity (terminated after a participant death)","phase":"Phase 2","n":120,"status":"TERMINATED"}],"sameAs":["https://pubchem.ncbi.nlm.nih.gov/compound/91971820"],"lastVerified":"2026-09-07","version":"1.0","published":true,"locale":"en","title":"CJC-1295 DAC: what the studies show, status and safety","summary":"CJC-1295 DAC is a lab-made copy of part of the natural hormone that tells the pituitary gland to release growth hormone. A chemical hook latches it onto a blood protein, so one injection keeps working for days rather than minutes. Three small studies in healthy people measured two blood values and nothing else. The only trial that would have tested a real health outcome was stopped in 2006 after a participant died, and it was never analysed. No country has approved it, and the world anti-doping list names it.","updated":"2026-09-07","url":"https://mypep.app/peptides/cjc-1295-dac"}